How Long Does Enclomiphene Take To Increase Testosterone? – Introduction
Testosterone is an extremely crucial hormone for the male reproductive system. Testosterone makes a man have deep voice, hair and muscles. Low testosterone leads to many health problems, including infertility, sexual dysfunction, and erectile dysfunction. Hence, it is necessary that testosterone levels in the body be at its highest. The drug Enclomiphene is used to treat low levels of testosterone in men. Here, we will talk about how enclomiphene acts and how long it takes to act.
How Long Does Enclomiphene Take To Increase Testosterone?
Enclomiphene is a selective estrogen receptor modulator (SERM) that increases production of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones stimulate the testes to release testosterone. Enclomiphene is a non-steroidal antidepressant, that means it does not contain testosterone. This makes it a safe and efficient supplement for low testosterone men.
How fast enclomiphene boosts testosterone varies by person. The time taken for enclomiphene to work varies with age, weight, and health status. It typically takes 4 to 12 weeks for enclomiphene to boost testosterone. Yet some studies have found that it takes up to 6 months for enclomiphene to make its full impact. Please note that enclomiphene will not raise testosterone in a single day, so you need to be patient for the best results.
Key Factors Influencing Testosterone Response
A number of factors can determine the degree and pace at which enclomiphene increases testosterone. Here are some critical considerations:
1. Age
Ageing is the moment when testosterone levels usually drop. Thus, physiological alterations can be the loss of the testicles and the decline in GnRH response in aged men. Thus, because of age, the response to enclomiphene might be less intense for older men than young men and needs being a little patient or taking more time to reach ideal testosterone levels.
2. Comorbidities and Medication
Several concurrent conditions (hepatic or renal insufficiency) may simply affect the metabolism and excretion of enclomiphene. A diminished organ function can impair the body’s processing ability and undermine drug efficiency. Further disturbances to the pharmacokinetics of enclomiphene can be caused by the simultaneous use of other medications, primarily those which alter the activity of cytochrome P450 enzymes and cause a variation in testosterone response.
3. Genetic Factors
Hence, genetic susceptibility may be only partially responsible for differences in response to enclomiphene treatments. Perhaps the root of this variation in treatment results lies in variations in genes involved in testosterone production, metabolism and receptor-receptor interactions. For instance, SNPs in testosterone-synthesis genes (CYP11A1, CYP17A1, and CYP19A1 encode cytochrome P450 enzymes) or SNPs in the AR gene can impact how well testosterone can be generated and how responsive cells are to currently available testosterone, thus influencing how well treated they are with enclomiphene.
4. Lifestyle Factors
A lifestyle factor plays an enormous role in the hormones’ health, which in turn influences the effectiveness of enclomiphene. These key considerations are diet, exercise routine, and other factors such as body mass index. For instance, excess body fat and restlessness may trigger an increase in aromatase activity that pushes the body to convert testosterone into estrogen. This conversion can be paralyzing to useful testosterone concentrations, thus again diminishing the effectiveness of enclomiphene. Conversely, a diet rich in sufficient protein, apart from exercise, can create a highly favourable hormonal environment. Therefore, a better lifestyle might boost the therapeutic efficacy of enclomiphene, increasing men’s likelihood of receiving their target testosterone levels.
Studies:
According to a 2010 paper, Katz et al. evaluated the efficacy and safety of enclomiphene in secondary hypogonadism (low testosterone because of a defect in the pituitary or hypothalamus). The group included 73 men, aged 54 on average, who received enclomiphene for 12 weeks. These tests revealed a significant boost in testosterone after only 4 weeks, increasing an average of 144 ng/dL. Maximum testosterone growth occurred after 12 weeks, at an average of 257 ng/dL. The article reveals that enclomiphene increases testosterone within 4 weeks.
The other study, by Katz et al in 2013, reported the same findings. assessed the effects of enclomiphene in the long term among men with secondary hypogonadism. In it, 46 men were prescribed enclomiphene for 6 months. The findings showed an increase in testosterone ranging from an average of 233 ng/dL up to 232 ng/dL. They also reported that the increase in testosterone remained throughout the 6-month study, with no serious side effects being noted.
Enclomiphene has also been contrasted with other medications that are used to cure low testosterone, including testosterone gels and injections. Miner et al (2016) published a 2016 study in which the authors studied the effects of cigarette smoke on lung cancer. compared the efficacy and safety of enclomiphene with testosterone gels in men with secondary hypogonadism. The study enrolled 142 men who were given either enclomiphene or testosterone gel for 16 weeks. The tests indicated comparable increases in testosterone in the two groups, and enclomiphene increased more consistently throughout the treatment cycle. Also, fewer side effects were observed in the enclomiphene group than in the testosterone gel group.
Conclusion: How Long Does Enclomiphene Take To Increase Testosterone?
The bottom line is that enclomiphene is an effective medication to boost testosterone in men with secondary hypogonadism. It also controls gonadotropin production and therefore encourages the testis to produce testosterone. It will take about 4 to 12 weeks for Enclomiphene to have its intended effect. However, it will still take some time for the full effect of this drug to come, and some studies have shown that enclomiphene may take up to 6 months to kick in. Enclomiphene is, over the years, as effective as other medicines for low testosterone. These, however, have fewer side-effects. There are still many studies to be conducted to determine its long-term testosterone effects.
